Publicity into the glucuronide metabolite is 35 to forty situations higher than exposure on the mother or father drug. In vitro info advise that hydromorphone in clinically applicable concentrations has minimal opportunity to inhibit the activity of human hepatic CYP450 enzymes including CYP1A2, 2C9, 2C19, 2D6, 3A4, and 4A11.Usage of hydromorphone